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Smallpox, highly contagious viral disease that is often fatal. The disease is chiefly characterized by a skin rash that develops on the face, chest, back, and limbs. Over the course of a week the rash develops into pustular (pus-filled) pimples resembling boils. In extreme cases the pustular pimples run together—usually an indication of a fatal infection. Death may result from a secondary bacterial infection of the pustules, from cell damage caused by the viral infection, or from heart attack or shock. In the latter stages of nonfatal cases, smallpox pustules become crusted, often leaving the survivor with permanent, pitted scars.
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